MCB Seminar | Using phylobiochemistry to understand the evolution of plant chemical diversity, Sept. 21

Tuesday, September 21, 2021 4:35pm to 5:30pm

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MCB Seminar | Using phylobiochemistry to understand the evolution of plant chemical diversity, Sept. 21

The Molecular & Cellular Biology Seminar series featured Ohio University alumnus Dr. Craig A. Schenck discussing "Using phylobiochemistry to understand the evolution of plant chemical diversity" on Tuesday, Sept 21, at 4:35 p.m. on Teams.

 

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+1 614-706-6572,,872959004#   United States, Columbus

Phone Conference ID: 872 959 004#

 

Schenck is assistant professor of biochemistry at the University of Missouri-Columbia. He earned a B.S. in Plant Biology - Cell/Biotech in 2010 and an M.S. in Molecular and Cellular Biology–Plant Biology in 2012 from the College of Arts & Sciences.

 

Contact Dr. Sarah Wyatt, MCB director, for more information.

 

Abstract: To cope with environmental pressures, plants produce an arsenal of structurally diverse chemicals, often called specialized metabolites. Specialized metabolites enable plants to interact with their environment and can deter, but also attract various organisms. Additionally, these compounds have been co-opted by humans and serve various medicinal, nutritional, and industrial roles. Lineage-specific specialized metabolites are derived from much simpler building blocks made by ubiquitous core metabolic pathways. Unlike well-documented diversification of plant specialized metabolic enzymes, core metabolic pathways are highly conserved and evolutionarily constrained, which makes manipulation of these pathways difficult. The expansion and alteration of core metabolism has given rise to the evolution of diverse plant specialized metabolites. However, the underlying mechanisms potentiating metabolic diversity and the connections linking core to specialized metabolism are not well known. Here, we used phylogeny-guided biochemical approaches to understand the evolutionary events that have shaped the chemical diversity of two distinct metabolic pathways. Divergence in core metabolism across the legume family has led to the emergence of a novel pathway for the biosynthesis of the amino acid tyrosine and has likely facilitated the evolution of downstream chemical diversity. Whereas the evolution of a class of specialized metabolites, acylsugars, in the Nicotiana genus, has been potentiated by enzyme promiscuity, altered pathway architecture and gene loss/gain events. Our goal is to harness the metabolic innovations in these and other pathways to increase crop resilience and enhance production of medicinal plant compounds through synthetic biology platforms.

 

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Microsoft Teams meeting

Join on your computer or mobile app

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Or call in (audio only)

+1 614-706-6572,,872959004#   United States, Columbus

Phone Conference ID: 872 959 004#

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