Molecular & Cellular Biology Seminar features Zohreh Shariati, March 29

The Molecular & Cellular Biology Seminar features Zohreh Shariati discussing "Lead (Pb) in lipsticks associated cellular toxicity: An interplay of oxidative stress and signal transduction" on March 29 from 4:35 to 5:55 p.m. in Porter Hall 104 and via Teams.

Shariati is a doctoral student in Molecular & Cellular Biology.

Join the meeting via Teams.

Abstract: Heavy metals including lead (Pb) can induce cellular toxicity and have become a critical health concern in biomedical science. Applying lead in different sectors, such as industrial, household and cosmetics poses a severe health concern. Lipsticks contain considerable amount of lead that can induce cellular toxicity. Oxidative stress is a prime cellular response, which is the result of an imbalance in the redox system that is associated with macromolecular damages and activation of cell survival and apoptosis pathways. Medical as well as experimental results suggest that oxidative stress-induced cellular response following lead exposure is associated with an increased risk of irreversible neurological defects and behavioral deformities, elevated blood pressure, bone deformities, hematological disorders, and neurodegeneration. Recently, a relation between lead exposure, oxidative stress, and signaling pathways have been investigated to understand the lead-induced toxicity. lead-induced oxidative stress and its association with different signaling pathways are complicated. The signaling pathways involved in this interplay include NRF2, JNK, NF-kB, and HIF.