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NQPI Seminar | Laser-ablative synthesis of multifunctional nanoparticles and nanocomposites for biomedical applications, Sept. 1

The Nanoscale and Quantum Phenomena Institute (NQPI) 's Seminar Forum series features Andrei V. Kabashin discussing Laser-ablative synthesis of multifunctional nanoparticles and nanocomposites for biomedical applications on Sept. 1 at 4:10 p.m. in Walter 245.

 

Kabashin is a professor at Aix-Marseille University in France.

 

Abstract: Based on a natural production of nanoclusters under the action of laser radiation on a solid target, laser ablation has proved its efficiency as a leading “physical” technology for the synthesis of nanomaterials. In contrast to conventional chemical synthesis, laser ablation provides non-equilibrium conditions for nanostructure growth and can be adapted for the fabrication of nanoparticles or composite nanostructures of virtually any material, while ultraclean conditions of synthesis make possible the avoidance of any toxic contamination. The presentation will briefly overview our on-going activities on laser ablative synthesis of novel biocompatible colloidal nanomaterials and their testing in biomedical tasks. Our original approach is based on ultra-short (fs) laser ablation from a solid target or already formed water-suspended colloids to fabricate “bare” (ligand-free) nanoparticles (NPs) with well-controlled size characteristics, as well as coating of nanomaterials by functional molecules (dextran, PEG etc.) during the ablation process or afterwards. The presentation will describe different laser-ablative approaches for the synthesis of metal/semimetal nanoparticles (Au, TiN, ZrN, B, Bi, etc), semiconductor/dielectric nanoparticles (Si, Sm2O3, organic dyes) and multifunctional composite nanostructures (Si@Au and Fe3O4@Au core-satellites) of prescribed characteristics. We will also present biomedical applications of these nanomaterials as contrast agents and probes in bioimaging (fluorescent imaging, magnetic resonance imaging, computer tomography, SERS-based bioidentification), sensitizers of therapies (photo- and radiofrequency-induced hyperthermia), and carriers of drugs (e.g., therapeutic radionuclides in nuclear medicine).  

 

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